The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2011Investigating Signaling Pathway Dysfunction Linked to LRRK2
Promising Outcomes of Original Grant:
Our project investigated whether LRRK2 had an impact on a particular signaling system in the cell called the mTOR pathway. This pathway helps to control how cells... -
Therapeutics Development Initiative, 2011Delivery of GDNF to the Brain by Novel Nanovesicles for the Treatment of PD
Objective/Rationale:
GDNF has the potential to halt the progression of, or reverse, PD. However, GDNF, a large protein, does not get into the brain when given orally or intravenously. Our novel nano... -
Therapeutics Development Initiative, 2011Dopamine D1 Positive Modulators for the Treatment of Parkinson's Disease
Objective/Rationale:
L-DOPA is the standard treatment of Parkinson’s disease (PD) but prolonged use results in dyskinesia. D2 agonists often require L-DOPA supplementation and can cause side effects... -
Rapid Response Innovation Awards, 2011Alpha-synuclein and Tau Mislocalization to Dendritic Spines
Objective/Rationale:
In addition to motor disorders, Parkinson disease (PD) patients also suffer from cognitive deficits, which are believed to result from abnormal accumulation of alpha-synuclein, a... -
Resource: Utilizing DATATOP Biospecimens, 2011Identification and Validation of Blood-borne Autoantibody Biomarkers for Parkinson's Disease
Objective/Rationale:
We recently discovered that self-reactive antibodies (autoantibodies) are abundant in blood and that detection of certain types of autoantibodies reveals the presence of disease... -
LRRK2, 2011Impact of LRRK2 Kinase Activity on Synaptic Vesicle Trafficking
Objective/Rationale:
The presynaptic alteration seen in several LRRK2 disease model suggest that LRRK2 might influence synaptic function through effects on presynaptic proteins. The common G2019S...
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Our funding programs support basic, translational and clinical research from academia and industry.