The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutics Development Initiative, 2012IMD-026259 - An Innovative Drug for Disease-Modifying Treatment of Parkinson´s Disease
Objective/Rationale:
IMD-026259 represents a proprietary highly potent and selective small molecule inhibitor of NF-kB pathway and 1 alpha (HIF-1alpha) mediated transcriptional activity. Comprehensive... -
MJFF Research Grant, 2012Gremlin-1, a Putative VTA-derived Neuroprotective Factor in Parkinson's Disease (Supplement)
Promising Outcomes of Original Grant:
We have previously postulated that the glycoprotein Gremlin has a neuroprotective role in PD. To test this hypothesis, we sought to develop a gremlin knockout pre... -
Target Validation, 2012Validation of Sirtuin 3 as a Neuroprotective Target in Parkinson’s Disease
Objective/Rationale:
Mitochondria are the major energy generators of a cell. Dysfunctional mitochondria are central to the pathology of Parkinson’s Disease (PD). We hypothesize that improving the... -
MJFF Research Grant, 2012Analysis of Archived Tissue from Parkin, DJ-1, PINK1 and LRRK2 KO Pre-Clinical Models
Objective/Rationale:
As part of a broad effort to develop preclinical models of Parkinson’s disease (PD), MJFF sponsored the generation and initial characterization of knockout pre...
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MJFF Research Grant, 2012Novel PD Tools: Generation of Posttranslationally Modified Alpha-synuclein
Objective/Rationale:
There is increasing evidence linking specific posttranslational modification (folding, cutting, etc. of proteins before maturation) and alpha-synuclein aggregation... -
Target Validation, 2012Validating Monoacylglycerol Lipase Inhibitors in Combatting Parkinson’s Disease
Objective/Rationale:
Chronic and persistent inflammation in the brain has been shown to be an underlying driver of Parkinson’s disease (PD). Anti-inflammatory strategies may be beneficial...
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Our funding programs support basic, translational and clinical research from academia and industry.