The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2011Gene Delivery of MiRNAs to Reduce Alpha-synuclein: A New Therapy for PD
Objective/Rationale:
Alpha synuclein is a protein that in excessive amounts is implicated in Parkinson’s disease (PD). Alpha synuclein is also known to be the major constituent of a signature... -
MJFF Research Grant, 2011Increasing the Sensitivity of LRRK2 Assays: Development of Proximity Ligation Assays for LRRK2
Objective/Rationale:
Inherited mutations in the enzyme LRRK2 are known to cause Parkinson’s disease (PD). Measuring the enzyme activity of LRRK2 in patient biological samples is difficult due to the... -
Rapid Response Innovation Awards, 2011How Does GBA1 Dysfunction Influence Parkinson's Disease?
Objective/Rationale:
Recent studies have revealed that defects in a gene known as GBA1 are the most common genetic cause of Parkinson’s disease (PD). The GBA1 gene is known to play a role in fat... -
Target Validation, 2011Regulatory T Cells as Modulators of Microglia's Inflammatory Response
Objective/Rationale:
Evidence in humans and in research models support a role for the immune system in the progression of Parkinson's disease. Local brain immune cells, called microglia, as well as... -
Therapeutics Development Initiative, 2011Proof of Concept of Treatment with Novel Hydroxypyridinone Iron Chelators in a Non-Clinical Model of Parkinson's Disease
Objective/Rationale:
We will test two novel, orally bioavailable, brain-penetrant iron chelators in a pre-clinical model of Parkinson’s disease (PD) for their ability to reduce labile iron-associated... -
MJFF Research Grant, 2011Structural, Post-translational Modification and Small Chemical Approaches to Understand LRRK2 Function in PD
Promising Outcomes of Original Grant:
Our original goal was to (1) establish electron microscopy (EM)-based dimeric structural assays for the LRRK2 protein and (2) develop high-throughput kinase assays...
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Our funding programs support basic, translational and clinical research from academia and industry.