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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Biomarkers, 2011
    GSTpi as a Blood Based Biomarker for Parkinson's Disease

    Objective/Rationale:
    The goal of this research project is to develop and validate a blood test that would identify individuals at risk for developing Parkinson’s disease and at a point in time prior...

  • MJFF Research Grant, 2011
    Multi-tracer positron emission tomography (PET) functional imaging as a tool to assess the relevance of rodent LRRK2 models to the human neurochemical phenotype associated with LRRK2 mutations related Parkinsonism

    Promising Outcomes of Original Grant:
    The goals of the original grant were to develop PET (a non invasive imaging technique used in the study of human Parkinson’s disease ) –derived measures of...

  • LRRK2, 2011
    LRRK2 Role on Auto-Antibody Production by Human B Cells

    Objective/Rationale:
    LRRK2 expression has been demonstrated in the brain and several organs, including the thymus and spleen, which are major immune system organs for B and T lymphocyte maturation...

  • Rapid Response Innovation Awards, 2011
    Functional Characterization of ATP13A2, a P-type Transport ATPase Involved in Neurodegeneration

    Objective/Rationale:
    Mutations in the ATP13A2 gene lead to the Kufor-Rakeb syndrome, a severe early-onset form of Parkinson’s disease (PD) with dementia. The ATP13A2 protein is targeted to cellular...

  • Resource: Utilizing DATATOP Biospecimens, 2011
    Using Human Cerebrospinal Fluid Samples Collected in DATATOP Study for Biomarker Validation in Patients with Parkinson disease

    Objective/Rationale:
    One of the major challenges in biomarker discovery/validation for Parkinson's disease (PD) is to define their utility in PD progression. This task is best tackled with the...

  • Rapid Response Innovation Awards, 2011
    Unlimited Discovery of Non-Coding, Regulatory RNAs and Aberrant Splicing in Parkinson's

    Objective/Rationale:
    The recent discovery of a hidden universe of regulatory, non-coding transcripts and previously unknown variants of protein-coding transcripts is challenging conventional thinking...

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