The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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GBA Biology and Therapies, 2019Resolving the Pathophysiology of Parkinson's Disease with GBA Mutations
Study Rationale:
Mutations in the GBA gene are the greatest genetic risk factor for developing Parkinson’s disease (PD). We will systematically examine pathophysiological pathways in PD patients with... -
GBA Biology and Therapies, 2019Identification of Targets of Neurotoxic Sphingolipids Using iPSCs from People with GBA-associated Parkinson’s Disease
Study Rationale:
GBA encodes the enzyme beta-glucocerebrosidase (GCase), which is required to maintain function of the cell’s lysosomes, which break down unnecessary cellular parts. Mutations in GBA... -
Alpha-Synuclein Biology and Therapies, 2019Development of a Novel Intracellular Alpha-synuclein-lowering Strategy based on CRISPR Interference Technology
Study Rationale:
Alpha-synuclein protein accumulates in the brain in Parkinson’s disease. Reducing the impact of this protein in the brain may prevent the degeneration of nerve cells and stop the... -
Research Grant, 2019PET Tracer to Support Trials of Drugs Inhibiting Neuroinflammation via the NLRP3 Inflammasome
Study Rationale:
Chronic inflammation of immune cells our brains is now believed to be associated with the onset and progression of Parkinson’s disease. These cells produce a target in Parkinson’s... -
Alpha-Synuclein Biology and Therapies, 2019Studying the Impact of Alpha-synuclein on Fatty Substances to Identify New Parkinson's Disease Drug Targets
Study Rationale:
Alpha-synuclein is a sticky protein that clumps in the brains of people with Parkinson's disease (PD). It can attach itself and interact with fatty substances called lipids and fatty... -
Research Grant, 2019Diagnosing Early-Stage Parkinson’s Disease via a Urine Test for Extracellular Vesicles
Objective/Rationale:
There is a great need to develop new, readily accessible biomarkers — objective measures of disease — from biofluids (blood, urine, saliva or cerebrospinal fluid) for early...
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Our funding programs support basic, translational and clinical research from academia and industry.