The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 Tools and Animal Models, 2018Tools for Studying Proteins LRRK2 and Rab35
Study Rationale:
Mutations in the LRRK2 gene are a leading genetic cause of Parkinson's disease (PD). One important function of the LRRK2 protein is to modify other proteins. Previously, we found that... -
Research Grant, 2018Studying Changes in Glucocerebrosidase Activity in People with Parkinson's Disease
Study Rationale:
A dysfunction of the glucocerebrosidase (GCase) protein increases the risk of Parkinson's disease (PD). Blood cells called monocytes produce large amounts of this protein. The aim of... -
Biosample Use Program, 2018MicroRNAs as Predictors and Measures of Parkinson's Disease
Study Rationale:
MicroRNAs (miRNAs) are molecules that control the production of proteins from genes in the cell. We have found that the blood of people with Parkinson's disease (PD) contains a lower... -
Research Grant, 2018Inflammatory Phenotypes in Differentiated Human LRRK2 and GBA Mutation IPS Cell Lines
Promising Outcomes of Original Grant:
With previous funding from MJFF, we determined how the activity of LRRK2 genetic mutations contributed to inflammation in Parkinson's. We found that inflammation... -
Research Grant, 2018Assess p935 LRRK2 and Total LRRK2 Levels Using an MSD Assay in Whole Blood
Study Rationale:
Some variants in the LRRK2 gene have been linked to increased risk of Parkinson's disease. This has made LRRK2 a promising target for Parkinson's drug development. To increase our... -
Research Grant, 2018Autologous Long-Term Cell Restorative Therapy for Parkinson's Disease
Study Rationale:
Cell replacement using induced pluripotent stem cells (iPSCs) is a potential restorative therapy for Parkinson's disease. Replacing brain cells that produce dopamine, a chemical...
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Our funding programs support basic, translational and clinical research from academia and industry.