The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2018Inducing Aging in Brain Cells to Better Understand Parkinson's Disease
Study Rationale:
Age is the biggest risk factor for Parkinson's disease (PD), with disease incidence rising steeply among persons 60 or older. The reason for this remains unknown. Research suggests... -
Therapeutic Pipeline Program, 2018Developing a Blocker of Alpha-synuclein Production for the Treatment of Parkinson's Disease
Study Rationale:
Alpha-synuclein is a sticky protein that clumps in the brains of people with Parkinson's disease (PD). Duplication or triplication of SNCA, a gene responsible for the production of... -
LEAPS, 2018Studying LRRK2 Mutations as a Possible Cause of Waste Buildup in Nerve Cells
Study Rationale:
Health and longevity of brain cells depends on the efficiency of their waste removal process, known as autophagy or self-eating. Cells use autophagy to get rid of unwanted protein... -
Target Advancement Program, 2018Validation of CD4 T Cell Dependent Neurotoxicity in an Alpha-Synuclein Model of Parkinson's Disease
Study Rationale:
Microglia, an immune cell in the brain, takes up unneccessary alpha-synuclein proteins and passes it on to the major histocompatibility complex (MHCII). This involves an interaction... -
Therapeutic Pipeline Program, 2018Dual Leucine Zipper Kinase Inhibitors for Parkinson's Disease
Study Rationale:
There are no therapies that slow down the loss of brain cells affected by Parkinson's disease. Prior research suggests that dual leucine zipper kinase (DLK) regulates stress response... -
Research Grant, 2018Peripheral Inflammatory Cytokine Profiling in Parkinson's Disease
Study Rationale:
A growing body of research suggests that inflammation contributes to Parkinson's disease. However, the stages in the disease process that inflammation is prevalent and important are...
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Our funding programs support basic, translational and clinical research from academia and industry.