The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Biomarkers Across Neurodegenerative Diseases, 2016Homo- and Hetero-aggregates as Biomarkers in Neurodegenerative Disorders
Study Rationale:
Neurodegenerative disorders like Alzheimer's and Parkinson's disease often have overlapping symptoms, which can make it difficult to differentiate them from one another in the clinic... -
Target Advancement Program, 2016Identifying Enzymes to Stimulate Alpha-synuclein Degradation
Study Rationale:
Rab GTPases, a family of small molecules that guide protein movement around cells, are linked to Parkinson's disease (PD). We have identified a group of Rabs with potential roles in... -
Research Grant, 2016Defining Structural Forms of Alpha-synuclein Responsible for Key Features Associated with Parkinson's Disease
Study Rationale:
The alpha-synuclein pre-formed fibril (PFF) model shows promise for modeling many features of Parkinson’s disease (PD). In this model, PFFs induce pathological features and behaviors... -
Research Grant, 2016Therapeutic Effects of XPro1595 on Motor and Non-motor Outcomes in a Pre-clinical Model of Parkinson's disease
Study Rationale:
Studies funded under the 2012 TDI award revealed that peripheral administration of XPro1595 in the 6-OHDA (neurotoxin) pre-clinical model afforded significant neuroprotection against... -
Improved Biomarkers and Clinical Outcome Measures, 2016Defining a Parkinson's Disease-specific Breath Fingerprint of Inflammatory and Neurodegenerative Processes
Study Rationale:
Breath analysis has the potential to be a powerful non-invasive screening tool to help a clinician determine the need for additional tests, a tool for routine interval screening of... -
Research Grant, 2016LRRK2 Function in Immunity
Study Rationale:
LRRK2 is expressed in immune cells but its function in these cells is unknown. It is also not known whether mutations (such as G2019S) in LRRK2 that cause familial (inherited)...
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Our funding programs support basic, translational and clinical research from academia and industry.