The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2016GBA Meta-analysis Initiative: Charting a Path to Success for Clinical Trials in Patients with GBA-PD
Promising Outcomes of Original Grant:
We ascertained the associations between GBA mutations and cognitive and motor outcomes in seven large cohorts representing 2,304 patients with PD (including 221... -
Therapeutic Pipeline Program, 2016Blocking Inflammasome-induced Neuroinflammation in Parkinson's Disease with a Potent, Orally Available Small Molecule
Study Rationale:
Our brains are full of immune cells called microglia, which fight infections and clear the brain of toxic products. In Parkinson's disease, these cells are constantly active, leading... -
Target Advancement Program, 2016Pharmacological Targeting of Proinflammatory Kinase Signaling in Parkinson's Disease
Study Rationale:
In Parkinson's disease, the brain's resident immune cells, called microglia, can become persistently activated due to the accumulation of alpha-synuclein-containing protein clumps... -
Target Advancement Program, 2016Targeting the Lysosomal Pathway to Ease Mitochondrial Dysfunction in IPSC-Derived Neurons from People with Parkinson's and GBA Mutations
Study Rationale:
Mutations of the GBA gene, which encodes the enzyme glucocerebrosidase (GCase), are associated with Parkinson's, and we have recently shown that loss of GCase activity gives rise to... -
Research Grant, 2016Role of the JAK/STAT Pathway in Parkinson's Disease
Promising Outcomes of Original Grant:
We aim to determine if hyperactivation of the JAK/STAT (cellular signaling) pathway is involved in Parkinson's disease pathology. Using a pre-clinical model of PD... -
Target Advancement Program, 2016Upregulation of Autophagy by Tet3-mediated 5-methylcytosine oxidation – Relevance to Parkinson's Disease
Study Rationale:
An abnormally folded version of the protein alpha-synuclein forms characteristic clumps (Lewy bodies) in nerve cells in Parkinson's disease (PD). One possible reason for this is an...
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Our funding programs support basic, translational and clinical research from academia and industry.