The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2016Investigation of LRRK2 as a Regulator of Dendritic Cell Function
Promising Outcomes of Original Grant:
Myeloid cells (white blood cells) of the immune system include monocytes, neutrophils and dendritic cells found in circulation, as well as microglia (immune system... -
Therapeutic Pipeline Program, 2016KH176 as a Novel Disease-modifying Therapeutic for Parkinson’s Disease
Study Rationale:
Mitochondrial dysfunction has a prominent role in the process of Parkinson’s disease (PD). Mutations in at least seven genes are known to underlie PD, most of them encode proteins that... -
Therapeutic Pipeline Program, 2016Long-term Cell Restorative Treatment for Parkinson’s Disease
Study Rationale:
Cell replacement therapies for Parkinson’s disease (PD) propose to replace the lost dopaminergic neurons in the brain. Transplanted fetal dopamine neurons have... -
Therapeutic Pipeline Program, 2016USP13 Regulation of Parkin Stability
Study Rationale:
Our data show that the enzyme USP13 is dramatically increased (two-fold) in sporadic Parkinson’s brains, and cell culture studies suggest that USP13 de-ubiquitinates... -
Target Advancement Program, 2016Targeting the Transcriptional Regulator of Autophagy LMX1B for Parkinson's Disease Therapeutic Development
Study Rationale:
LMX1B is a transcription factor that plays an essential role in the development of dopaminergic neurons. We have recently described a new role for LMX1B in dopaminergic neurons as a... -
Target Advancement Program, 2016Role of LRRK2 in GCase-mediated Alterations in Lysosome Function and Alpha-synuclein Metabolism
Study Rationale:
Mutations in the lysosomal (enzyme storage unit) enzyme GCase are associated with an increased risk of Parkinson's disease (PD) and cause alpha-synuclein (protein associated with...
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Our funding programs support basic, translational and clinical research from academia and industry.