The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Target Advancement Program, 2016Role of LRRK2 in Levodopa-induced Dyskinesia
Study Rationale:
Alterations in the gene LRRK2 are associated with inherited forms of Parkinson's disease (PD). Although it remains unclear why changes in LRRK2 cause the disease, the majority of... -
Therapeutic Pipeline Program, 2016Structure Window into LRRK2: Kinase or Pseudokinase?
Study Rationale:
Our present understanding of LRRK2 is held back by a lack of structural information. Our
interdisciplinary team will solve structures of specific familial (inherited) mutants of LRRK2... -
Research Grant, 2016Structural Studies on LRRK2 Kinase Using X-Ray Crystallography
Promising Outcomes of Original Grant:
Our initial grant, led by Dr. Susan Taylor, focused on the structural organization of a protein called LRRK2, an enzyme that transfers small chemical groups called... -
Research Grant, 2016Characterization, Optimization and Validation of a Preformed Fibril Pre-clinical Model of Parkinson's Disease
Study Rationale:
New pre-clinical models have been developed to study the hypothesis that damaging forms of alpha-synuclein (protein involved in Parkinson's) spread across brain regions from a single... -
Research Grant, 2016Design and Identification of a LRRK2 Kinase Structural Surrogate
Study Rationale:
Due to the importance of the LRRK2 protein in Parkinson's disease (PD), many academic and industrial laboratories have attempted to solve the three-dimensional structure of the kinase...
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Target Advancement Program, 2016Targeting the Transcriptional Regulator of Autophagy LMX1B for Parkinson's Disease Therapeutic Development
Study Rationale:
LMX1B is a transcription factor that plays an essential role in the development of dopaminergic neurons. We have recently described a new role for LMX1B in dopaminergic neurons as a...
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Our funding programs support basic, translational and clinical research from academia and industry.