Funded Studies

Study Rationale:
This study is a search for biomarkers of Parkinson’s disease (PD) that would provide early diagnostic clues or a means to monitor disease progression (or both). The analysis involves...

Study Rationale:                  
Mutations in the gene that encodes the LRRK2 protein are frequent causes of Parkinson’s disease (PD). An obstacle to understanding how these mutations lead to PD is...

Study Rationale:                   
Over-activation of brain immune cells, called microglia, is associated with the degeneration that occurs in Parkinson’s disease. This suggests that brain...

Study Rationale:                   
Speech and voice disorders are common in people with Parkinson’s disease (PD) and adversely affect their communication and quality of life. Presently, Lee Silverman...

Study Rationale:
A major challenge in Parkinson’s treatment is the management of levodopa-induced dyskinesias. A promising approach is offered by non-invasive neuromodulation techniques. We recently...

Study Rationale:                   
The dopamine precursor levodopa is the gold-standard treatment for Parkinson’s disease. However, as PD progresses, serotonin neurons increasingly convert levodopa to...