The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 Biology Consortium, 2017Describing the Structure and Function of LRRK2
Study Rationale:
Although leucine-rich repeat kinase 2 (LRRK2) is the greatest known genetic contributor to Parkinson's disease (PD), little is known about its structure and function. To better... -
Research Grant, 2017Using Neural Cells to Test New Drugs that Activate PINK1 and Parkin
Promising Outcomes of Original Grant:
Even though most people with Parkinson's disease (PD) do not have a genetic mutation -- a change in their DNA -- that causes the disease, genes can influence the... -
Access to Data and Biospecimens, 2018Uric Acid as an Antioxidant Treatment for LRRK2-associated Inherited Parkinson's Disease
Objective/Rationale:
Uric acid is a chemical produced naturally in the human body. In this project, we aim to investigate whether uric acid is an antioxidant capable of reducing the risk of Parkinson's... -
Research Grant, 2018Does Mitochondrial Dysfunction in the Skin Predict That in the Brain?
Study Rationale:
Mitochondria -- the power generators of the cell -- do not function properly in Parkinson's disease (PD). This dysfunction, however, is not always present and can vary in its severity... -
Biomarkers Across Neurodegenerative Diseases, 2018Brain Networks as Targets of Neurodegeneration in Parkinson's and Alzheimer's Diseases
Study Rationale:
This study builds on two recent discoveries in neuroscience: first, the brain is organized in large-scale networks of nerve cells; and second, the clumps of alpha-synuclein, amyloid... -
Research Grant, 2018Searching for New Genes That Control Mitochondrial Self-Eating
Study Rationale:
Two proteins, PINK1 and parkin, keep cells healthy by breaking down damaged mitochondria, cell's energy generators. This process is known as mitophagy or mitochondrial self-eating...
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Our funding programs support basic, translational and clinical research from academia and industry.