The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 Challenge, 2014Role of LRRK2 in the Regulation of Dopamine Receptor Trafficking
Study Rationale:
Mutation of the LRRK2 gene is the greatest known genetic contributor to Parkinson’s disease. However, the molecular mechanisms and pathological pathways by which LRRK2 induces neuronal... -
Therapeutic Pipeline Program, 2014Cell Assays to Measure Peripheral Response to GCase Activators
Objective/Rationale:
Individuals who carry one copy of the gene for Gaucher’s disease are at significantly increased risk of Parkinson’s disease. Lysosomal Therapeutics Inc. (LTI) is... -
Access to Data and Biospecimens, 2014Metabolomic Analysis of Parkinsonian Disorders
Study Rationale:
This study is a search for biomarkers of Parkinson’s disease (PD) that would provide early diagnostic clues or a means to monitor disease progression (or both). The analysis involves... -
Rapid Response Innovation Awards, 2014Directed Evolution of Bacteria for Recombinant Expression and Purification of LRRK2
Study Rationale:
Mutations in the gene that encodes the LRRK2 protein are frequent causes of Parkinson’s disease (PD). An obstacle to understanding how these mutations lead to PD is... -
Rapid Response Innovation Awards, 2014Defining the Contribution of Neuroinflammation to Parkinson's Disease
Study Rationale:
Over-activation of brain immune cells, called microglia, is associated with the degeneration that occurs in Parkinson’s disease. This suggests that brain... -
Therapeutic Pipeline Program, 2014Augmenting Treatment Effects of Voice Therapy in Parkinson’s Disease
Study Rationale:
Speech and voice disorders are common in people with Parkinson’s disease (PD) and adversely affect their communication and quality of life. Presently, Lee Silverman...
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Our funding programs support basic, translational and clinical research from academia and industry.