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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • LRRK2 LEAPS, 2014
    Link between LRRK2, Alpha-synuclein and Lysosomal Function

    Study Rationale:
    Our goal is to test whether Parkinson’s disease (PD) patients carrying a LRRK2 mutation have an abnormality in their lysosomes, a part of a cell that is necessary for degrading waste...

  • Alpha-synuclein Pathology, 2014
    Contrasting Pathological Versus Normal Alpha-synuclein Assemblies

    Study Rationale:                   
    Parkinson’s disease (PD) is characterized by Lewy bodies composed of the protein alpha-synuclein in dopamine-producing nerve cells. The protein aggregates are also...

  • Alpha-synuclein Pathology, 2014
    Characterization and Validation of Disease-specific Alpha-synuclein Species

    Study Rationale
    Alpha-synuclein aggregates called Lewy bodies are the hallmark of Parkinson’s disease (PD). Methods to measure alpha-synuclein in cerebrospinal fluid do exist today. However, these...

  • Alpha-synuclein Pathology, 2014
    Characterization and Validation of Disease-specific Alpha-synuclein Species in Cerebrospinal Fluid

    Study Rationale:                   
    The protein alpha-synuclein plays a major role in Parkinson’s disease (PD). Quantification of alpha-synuclein in biological fluids (e.g., cerebrospinal fluid) could...

  • Access to Data and Biospecimens, 2014
    Purine Biomarkers of LRRK2 PD

    Objective/Rationale:             
    Oxidative damage to brain cells — akin to rust on car parts — can build up in Parkinson’s disease (PD) and leads to break down of brain functions. Urate is a natural...

  • Access to Data and Biospecimens, 2014
    LRRK2 in Urine as a Biomarker for PD

    Objective/Rationale:             
    A mutation in the LRRK2 gene is the most common known genetic cause of Parkinson’s disease (PD). Not everyone who has the LRRK2 mutation will develop PD, but there are...

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