The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Parkin Therapeutic Development, 2014Identification of Small Molecules that Stabilize Parkin in an Active Conformation
Objective/Rationale:
Parkin is a protein linked to hereditary, young-onset Parkinson’s disease (PD) through a series of genetic mutations. Its formal role in PD is not fully understood, but its... -
Research Grant, 2014Parkin-mediated Mitigation of Neurodegeneration Induced by Overexpression of Alpha-synuclein Using AAV Vectors
Objective/Rationale:
Mutations in the gene for the protein parkin gene can cause Parkinson’s disease (PD), and parkin is involved in the breakdown of damaged proteins. This makes parkin an important... -
Rapid Response Innovation Awards, 2014Identification of the Parkin-binding Domain for SLP-2 as a Potential Therapeutic Target
Objective/Rationale:
Defects in mitochondria (the “powerhouse” of the cell) are implicated in Parkinson’s disease (PD), and the protein parkin is known to be involved in controlling mitochondrial... -
PPMI Sample Request, 2014Whole Blood RNA Biomarkers of Parkinson’s Disease
Objective/Rationale:
When a Parkinson’s disease patient first experiences motor symptoms, most of the neurons in the part of the brain affected by the disease have already died and therefore the... -
Research Grant, 2014Role of LRRK2 in Dopamine Modulation of Striatal Glutamate Transmission
Objective/Rationale:
Many of the motor symptoms in Parkinson’s disease (PD) are attributed to a deficit of the neurotransmitter dopamine in the brain region called the striatum. Recent studies show... -
Target Validation, 2014CISD1 (mitoNEET) as a Mitochondrial Drug Target in Parkinson’s Disease
Objective/Rationale:
Mitochondrial dysfunction and oxidative stress contributes to the death of the brain cells seen in Parkinson’s disease. The mitochondrial protein mitoNEET (encoded by the gene...
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Our funding programs support basic, translational and clinical research from academia and industry.