The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Parkin Biology, 2014Function of Parkin-mediated Ubiquitination in Synaptic Function
Objective/Rationale:
Researchers know that the protein parkin is associated with Parkinson’s disease (PD), but need to know more about its pathways and processes to target it with... -
Parkin Biology, 2014Parkin Modulates Neuroinflammation to Sustain Dopaminergic Neuronal Health
Objective/Rationale:
People with mutations in the Parkin gene can develop young-onset Parkinson’s disease (PD). The protein parkin (genes encode proteins) modifies the structure of many other cell... -
LRRK2 Role in Idiopathic Parkinson's Disease, 2014Use of Lrrk2-associated Cellular Fingerprints to Link Familial Forms to Idiopathic Forms of Parkinson’s Disease
Objective/Rationale:
Clinical and genetic findings have established a clear link between the LRRR2 gene and Parkinson’s disease. To what extent and by what mechanisms LRRK2 contributes to... -
Research Grant, 2014Direct Reprogramming of Functional, Induced Dopaminergic Neurons from Human Adult Somatic Cells
Promising Outcomes of Original Grant:
We have established a new procedure to directly convert skin fibroblasts (a type of cell) from pre-clinical models into induced dopaminergic (iDA) neurons. We have... -
Rapid Response Innovation Awards, 2014Rating Segmental Progression of Cardinal Motor Symptoms in Early Parkinson's Disease
Objective/Rationale:
We recently reported a new, practical approach to rate segmental progression of cardinal motor symptoms in Parkinson's disease (PD) at early stages. We computed four new scores —... -
Access to Data and Biospecimens, 2014Contribution of the Unfolded Protein Response to Idiopathic and LRRK2-driven Parkinson’s Disease
Objective/Rationale:
The unfolded protein response (UPR) is a life-death switch that instructs aged and overworked cells to self-destruct. We hypothesize that hyper-activation of the UPR...
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Our funding programs support basic, translational and clinical research from academia and industry.