The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2013Evaluation of the RXR Agonist Compound IRX4204
Study Rationale:
Drugs that activate the retinoid X nuclear receptor (RXR) have been reported to promote survival of dopaminergic neurons in previously published pre-clinical studies. IRX4204 is a... -
Clinicopathological Correlations for PD, 2012Identification of Alpha-synuclein Molecular Forms Correlating with Clinicopathology
Promising Outcomes of Original Grant:
We have developed a sensitive method for profiling alpha synuclein and its processed forms (“alpha synucleome”) from minimal clinical model brain tissue using... -
RRIA 2012 (Rapid Response Innovation Awards), 2012Novel Protease Pathway in Parkinson’s Disease
Objective/Rationale:
Mitochondria are essential for generating energy for all the cells in the human body. Many human diseases are caused by malfunctions in mitochondria, including Parkinson’s... -
Improving Levodopa Delivery, 2012Enhanced Dopamine Availability, Prolonged Activity and Improved Dyskinesia Profile After Administration of Selectively Deuterated Levodopa
Objective/Rationale:
To confirm the found beneficial effects of DP-102 (reduced dyskinetic effects at motoric equieffective doses in comparison to regular levodopa) in a pre-clinical model of Parkinson... -
LRRK2 Biology LEAPS, 2012Combining Mass Spectrometry with Genetic and Pharmacological Approaches to Discover and Validate LRRK2 Substrates
Objective/Rationale:
Much recent work has suggested that comprehending the biological properties of an enzyme termed LRRK2 that is mutated in about one percent of all Parkinson’s disease patients... -
Rapid Response Innovation Awards, 2012Development of Small Molecule Hepatocyte Growth Factor Mimetics for the Treatment of Parkinson’s Disease
Objective/Rationale:
The goal of this project is to determine the clinical potential of a novel, orally active hepatocyte growth factor mimetic for the prevention and/or treatment of Parkinson’s...
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Our funding programs support basic, translational and clinical research from academia and industry.