The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 Pharmacodynamic Assays, 2013Monocyte Monitoring in LRRK2-associated Parkinson’s Disease
Objective/Rationale:
LRRK2 variants significantly contribute to the development of familial and sporadic Parkinson’s disease (PD). However, it is not yet understood how LRRK2 mutations cause cellular... -
Research Grant, 2013Evaluation of a LRRK2 Inhibitor in the Partial 6-OHDA-lesioned Model of Parkinson’s Disease
Objective/Rationale:
Mutations in the LRRK2 gene are the most common cause of familial Parkinson’s disease (PD). The existing human genetic, cell-based and model data suggest that LRRK2 kinase... -
Research Grant, 2013Using Whole Genome Sequencing Data from LRRK2 Families to Identify Novel Rare Variants of LRRK2-associated Parkinson’s Disease
Objective/Rationale:
The age of onset and penetrance (likelihood of disease) of individuals with the LRRK2 G2019S mutation varies considerably, the latter ranging in some families from as high as 100... -
Clinical Intervention Awards, 2013Dipraglurant for Levodopa-Induced Dyskinesia Pre-phase IIB Studies
Study Rationale:
Dipraglurant is a modulator of the metabotropic glutamate receptor 5 (mGluR5). Blockade of this receptor has been shown to have anti-parkinsonian and anti-dyskinetic... -
Cognition Biomarkers, 2013Alpha-synuclein and Cognitive Decline in Parkinson’s Disease
Objective/Rationale:
Variability in the SNCA gene (which encodes alpha-synuclein, the protein that clumps in Parkinson’s disease) is a major risk factor for PD. Using next-generation... -
Research Grant, 2013Comprehensive Structural and Molecular Phenotyping of Parkinson’s Disease Models
Objective/Rationale:
Parkinson’s disease (PD) pre-clinical models carrying relevant human PD gene mutations can provide important insights into the molecular mechanisms implicated in PD...
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Our funding programs support basic, translational and clinical research from academia and industry.