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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2012
    The Transfer of Alpha-Synuclein: Mechanistic and Therapeutic Studies

    Objective/Rationale:
    This three-year collaborative project between three seasoned Parkinson’s disease (PD) investigators capitalizes on their extensive PD research experience and new understanding of...

  • Rapid Response Innovation Awards, 2012
    Reversing Pre-existing Pathologies of Dopamine Neurons in an Alpha-synuclein Model

    Objective/Rationale:             
    Alpha-synuclein has been identified to play the central role in Parkinson’s disease. Genome-wide association studies confirm alpha-synuclein as a risk factor for...

  • Target Validation, 2012
    Small Molecule Ligand for TrkB/TrkC as a Novel Therapeutic for Parkinson's Disease

    Objective/Rationale:        
    Ample evidence suggests that the neurotrophin (NT) receptors, TrkB and TrkC, would be particularly effective therapeutic targets for Parkinson’s disease (PD). Both...

  • LRRK2 in the Immune System, 2012
    The Four Horsemen of G2019S

    Objective/Rationale:             
    Using stem cell-derived neurons from individuals with Parkinson’s disease, we have found that dopaminergic neurons carrying the G2019S variant of LRRK2 are abnormally...

  • MJFF Research Grant, 2012
    Investigation of Possible Pathological Changes in Aged LRRK2 Knockout Models

    Objective/Rationale:             
    To determine if there are any pathological changes in either the brain, kidney, lung, spleen, liver, and heart in aged LRRK2 knockout and wild type pre-clinical...

  • MJFF Research Grant, 2012
    Role of LRRK2 in Alpha-Synuclein-Induced Neurodegeneration

    Objective/Rationale:
    This project seeks to develop a robust and standardized pre-clinical model relevant to late-onset Parkinson’s disease (PD) that will identify clinically viable LRRK2 kinase...

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