The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2012In Vivo Characterization of Helper-dependent Adenoviral Vectors Expressing Human LRRK2
Objective/Rationale:
Mutations in the LRRK2 gene are a common cause of familial Parkinson’s disease. Familial LRRK2 mutations induce neuronal toxicity in vitro. Reliable pre-clinical... -
Rapid Response Innovation Awards, 2012Reversing Pre-existing Pathologies of Dopamine Neurons in an Alpha-synuclein Model
Objective/Rationale:
Alpha-synuclein has been identified to play the central role in Parkinson’s disease. Genome-wide association studies confirm alpha-synuclein as a risk factor for... -
Therapeutics Development Initiative, 2012Anti-parkinsonian and Anti-dyskinetic Efficacy of HE3286 in a Model of Parkinson’s Disease
Objective/Rationale:
HE3286 is an anti-inflammatory drug in phase II clinical trials for other diseases that is being evaluated for treatment of Parkinson’s disease (PD). HE3286 taken orally rapidly... -
Target Validation, 2012VPS35 as a Novel Target for Parkinson's Disease
Objective/Rationale:
Mutations in the VPS35 gene were recently identified as a cause of autosomal dominant familial Parkinson's disease (PD). How mutations in VPS35 precipitate the demise of...
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Biomarker Development, 2012The Fox Investigation for New Discovery of Biomarkers (BioFIND)
Objective/Rationale:
Biomarkers — a biological marker of disease presence or risk like cholesterol level for heart disease — will greatly aid clinicians’ ability to diagnose Parkinson’s... -
Critical Challenges in PD: Postural Instability and Gait Dis, 2012Targeted Cognitive Training Program for Freezing of Gait
Promising Outcomes of Original Grant:
In our original study we investigated the processes underlying the freezing phenomenon in PD. In this work we found symptoms of freezing of gait (FOG) could be...
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Our funding programs support basic, translational and clinical research from academia and industry.