The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 Target Engagement Ligand, 2011LRRK2 Target Engagement Ligand
Objective/Rationale:
Target engagement ligands, also known as imaging agents, are useful tools in the development of drugs and this project seeks to develop such a tool for Leucine Rich Repeat Kinase... -
Rapid Response Innovation Awards, 2011Regulated GDNF Gene Therapy: a Novel Regulatory System Based on Protein Degradation
Objective/Rationale:
Gene therapy may offer effective treatments to patients. Delivering genes to cells in the body has the potential of letting the patient’s cells treat themselves. In the case of... -
MJFF Research Grant, 2011Global Estimates for the Role of LRRK2 Variation in Parkinson's Disease Susceptibility
Promising Outcomes of Original Grant:
Our original goal was to resolve the role of known LRRK2 coding variants in susceptibility to Parkinson’s disease. Our studies have nominated risk factors for... -
Research Grant, 2011Targeting Glia in PD with Novel Anti-inflammatory Therapeutics
Objective/Rationale:
Loss of dopamine-producing neurons in Parkinson’s disease (PD) is accompanied by inflammation in surrounding support cells, called glial cells. This inflammatory state in glial... -
LRRK2 Target Engagement Ligand, 2011Development of LRRK2 Target Engagement Ligands
Objective/Rationale:
The overall objective of this project is to generate the data necessary to ultimately identify a small organic molecule capable of binding to a sub-domain of the LRRK2 protein... -
MJFF Research Grant, 2011Development of Functional Imaging for CB-1 and 5-HT1a in PD Participants with Dyskinesia
Objective/Rationale:
The goal of this proposal is to develop two imaging tests, [18F]MK-9470 and [18F]MPPF, to assess the function of two receptors (cannabinoid – CB-1 and serotonin receptor – 5-HT1a...
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Our funding programs support basic, translational and clinical research from academia and industry.