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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Repositioning Drugs for PD, 2011
    Evaluation of a Specific DAT Inhibitor in Pre-clinical Models of Parkinson's Disease

    Objective/Rationale: 
    MLR-1017 is a psychostimulant drug used clinically for a variety of neuropsychiatric and other applications, but has never been tested in Parkinson’s disease (PD). Levodopa is a...

  • Target Validation, 2011
    Pathway Validation of a Biased Delta Opioid Receptor Ligand for PD Symptoms & Side Effects Relief

    Objective/Rationale:
    Endogenous activation of the Delta opioid receptor (DOR) serves as a compensatory mechanism to alleviate Parkinson’s disease (PD) symptoms. However, DOR-mediated convulsions have...

  • Rapid Response Innovation Awards, 2014
    Levodopa Versus Dopamine Agonist after Deep Brain Stimulation in Parkinson's Disease

    Study Rationale:                   
    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for patients with advanced Parkinson's disease (PD). STN DBS improves motor...

  • Repositioning Drugs for PD, 2011
    Duloxetine Hydrochloride as a Novel Neuroprotective Treatment for Parkinson's Disease

    Objective/Rationale: 
    In Parkinson’s disease (PD) dopaminergic neurons in the midbrain region substantia nigra pars compacta die. There is currently no treatment available that prevents this cell death...

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