The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2006PDGene
Parkinson’s disease is a genetically complex and heterogeneous disorder. To date, mutations in five genes have been identified to cause early-onset parkinsonism, which typically follows Mendelian...
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MJFF Research Grant, 2006California Parkinson's Disease Registry Pilot Project
Much remains to be elucidated about causes of Parkinson’s disease, a progressive neurodegenerative condition that affects at least 1,000,000 people in the United States. For example, little detailed...
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Development of Progressive Pre-clinical Models of PD, 2006Generation of Transgenic Mice with Selective and Progressive Loss of Nigrostriatal Dopaminergic Neurons
Mutations in the alpha-synuclein gene are responsible for rare, dominantly inherited forms of familial Parkinson's disease, designated PARK1 and PARK4. Furthermore, alpha-synuclein is also the major...
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Development of Progressive Pre-clinical Models of PD, 2006P1 Artificial Chromosome Transgenic Mice as models for Progressive Parkinson Disease
Although most cases of Parkinson's disease occur without a family history, there are examples of highly hereditary forms of the disease. One rare form of hereditary PD is caused by alterations in a...
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Development of Progressive Pre-clinical Models of PD, 2006LRRK2 and PD Genetic Pre-clinical Models
The cause of Parkinson's in most patients is unknown, but in a small percentage of cases (three to five percent), mutation in a specific gene is causal. Several genes have been conclusively linked to...
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Development of Progressive Pre-clinical Models of PD, 2006Inflammatory Stimuli as 'Second-Hit' Triggers for Development of Progressive Nigral Degeneration
Parkin and DJ-1 knockout mice model the recessively inherited loss-of-function mutations in these genes that cause human parkinsonism. Despite significant nigrostriatal dysfunction in both knockout...
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Our funding programs support basic, translational and clinical research from academia and industry.