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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Spring 2025 RFA: Molecular MRI Biomarker Program, 2026
    Mapping Mitochondrial Dysfunction in Parkinson’s Disease Using 15N-Magnetic Resonance of Nicotinamide Metabolism (MiND15)

    Study Rationale:

    In Parkinson’s disease, one of the earliest problems in the brain is a failure of mitochondria—tiny structures that produce energy for cells. This energy failure happens before many...

  • Spring 2025 RFP: Accelerating Biological Understanding and Therapeutic Translation for PD- Biology, 2026
    Bidirectional Genome-wide CRISPRi/a Screening Using Ratiometric GCase Substrates to Identify Genetic Modulators of Lysosomal GCase Activity

    Study Rationale:  

    Mutations in the gene GBA1, are the most common genetic risk factor for Parkinson Disease (PD)Mutations in GBA1 lead to malfunctioning of the protein glucocerebrosidase, which acts...

  • Spring 2025 RFP: Accelerating Biological Understanding and Therapeutic Translation for PD- Biology, 2026
    Deciphering Intracellular Pathways Altered by LRRK2 Kinase Activity and Phospho-RAB Effector Function

    Study Rationale:                   

    Gain-of-function mutations in LRRK2 cause familial Parkinson’s disease (PD) and increase the risk of developing the sporadic form of the disease. However, how...

  • Summer 2025 RFA: Personalized Approaches for Understanding, Assessing and Improving Gait in Parkinson’s Disease Research Program, 2026
    A Novel Digital Music-based Autonomous Personalized Walking Intervention to Improve Gait and Walking Automaticity in Parkinson Disease

    Study Rationale:

    People with Parkinson disease often take small, slow and unsteady steps, which makes it hard to get around and lowers their quality of life. While focusing on walking can help a little...

  • Fall 2025 RFP: Data Advice To Action - DATA-PD, 2026
    Blood-based Signatures of CSF Synuclein SAA Positivity

    Study Rationale:                   

    The ability to identify people during life, who are likely to have underlying Lewy body pathology has been a game-changer. However, the current test (SAA) is limited...

  • Research Grant, 2026
    From Functional Maps to Clinical Outcomes: Interpreting GBA1 Variant Effects in Parkinson's Disease

    Study Rationale:                   

    Genetic variants in the GBA1 gene are among the most important risk factors for Parkinson’s disease. GBA1 encodes an enzyme that breaks down waste inside lysosomes...

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