The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutic Pipeline Program, 2021Brain-penetrating Antisense Oligonucleotide to Down-regulate Alpha-synuclein
Study Rationale:
Antisense oligonucleotides (ASOs) are a new type of therapeutic that have promise for treating Parkinson’s disease. They act by modifying the production of specific proteins, such as... -
Research Grant, 2020California Parkinson’s Disease Registry
Study Rationale:
This project will support operations and enhancement of the California Parkinson’s Disease Registry (CPDR) for one year. CPDR captures and stores information on all Parkinson’s... -
Priority Biology, 2020Effects of LRRK2 Variants on GCase Activity in iPSC-derived Dopamine Neurons and Microglia
Study Rationale:
There is contradictory evidence on whether the LRRK2 and GBA genes, and the proteins that they encode, interact in their effects on Parkinson’s disease. Some studies suggest that... -
Research Grant, 2020Evaluation of ANAVEX2-73 (blarcamesine) in Participants with Parkinson’s Disease
Study Rationale:
We are testing ANAVEX2-73 (also known as blarcamesine), which previous research has shown helps improve behaviors as well as normalizes biochemical changes in a Parkinson’s... -
, 2020The Role of USP30 in Idiopathic Parkinson’s Disease
Study Rationale:
Dopamine neurons are highly vulnerable to age-dependent increases in mitochondrial dysfunction, oxidative stress, and protein accumulation due to their high metabolic activity... -
Research Grant, 2020Biomarker for Mitophagy Pathway Activation
Study Rationale:
Abnormal PINK1-PRKN directed mitochondrial quality control appears to be an important contributor to Parkinson’s disease (PD). Measures to assess activation of this pathway in...
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Our funding programs support basic, translational and clinical research from academia and industry.