The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2019Targeting LRRK2 in Models of Gastrointestinal Inflammation
Study Rationale:
We seek to investigate the extent to which gut inflammation triggers brain inflammation and Parkinson’s-like pathology and the role of LRRK2 and Tumor Necrosis Factor (TNF)-dependent... -
LRRK2 Biology Consortium, 2019Biochemical and Structural Characterization of LRRK2-specific Nanobodies
Study Rationale:
Malfunctioning of the protein leucine-rich repeat kinase 2 (LRRK2) is a common genetic cause of Parkinson’s disease (PD). LRRK2 is a very large and complex protein, and insight into t... -
Research Grant, 2019Functional Evaluation of Alpha-synuclein Dosage Effects in CRISPR‐edited SNCA Model
Promising Outcomes of Original Grant:
The goal of our original grant was to develop a patient-derived stem cell model from skin cells with different expression levels of protein alpha-synuclein, which... -
Target Advancement Program, 2019Targeting Necroptosis to Stop Axonal Degeneration in Parkinson's Disease
Study Rationale:
Parkinson’s disease (PD) is caused by degeneration of dopamine neurons. Neurons are constituted by a cell body and projections called axons by which neurons communicate... -
Therapeutic Pipeline Program, 2019CRISPRi/dCas9 Downregulation of Alpha-synuclein as a Novel Gene Therapy
Study Rationale:
Neurodegeneration in the brains of people with Parkinson’s may be caused by protein clumps called Lewy bodies, the pathological hallmark of the disease. Lewy bodies consist of a... -
Improved Biomarkers and Clinical Outcome Measures, 2019Correlating MRI, Pathology and Cognitive Assessments toward Biomarkers of Cognitive Decline
Study Rationale:
Parkinson’s studies are working to identify magnetic resonance imaging (MRI) biomarkers for early diagnosis, disease severity and progression. However, attempts to explore how brain...
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Our funding programs support basic, translational and clinical research from academia and industry.