Study Rationale: The study will analyze clinical PET data from 5 subjects imaged dynamically with 18F-DPA714, an imaging larker for brain inflammation. The purpose of the study is to ensure that reliable data has been acquired and can be analyzed using tracer kinetic analysis methods.
Hypothesis: Determine whether the 18F-DPA714 dynamic PET data be successfully analysed and compared dynamic data derived outcome measures with static SUVR outcome measures.
Study Design: Arterial input functions will be generated using the available plasma and metabolite data. These data will then be used in conjunction with an appropriate plasma input tracer kinetic analysis model to quantify regional outcome measures of TSPO binding. These results will be compared with SUVR values derived from a late time window.
Impact on Diagnosis/Treatment of Parkinson’s disease: Imaging biomarkers of neuroinflammation could be valuable tools for understanding disease progression and response to treatment.
Next Steps for Development: Further clinical 18F-DPA714 PET data will be acquired as part of the ongoing PPMI sub-study and information from this work will help confirm the suitability of the chosen static SUVR window.