We have identified stem cells in post-natal marrow of humans and animals that can be induced to differentiate at the clonal level to cells of mesodermal, neuroectodermal, and endodermal origin. Specifically, we have shown that they differentiate into functioning neurons as well as astrocytes and oligodendrocytes. The goal of this project is to further characterize the in vitro neuronal differentiation, with specific emphasis on dopaminergic neurons, and test whether transplantation in 6-OHDA treated animals will support differentiation in vitro and restoration of striatal function in vivo.
Researchers
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Catherine M. Verfaillie, MD