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Laura Volpicelli-Daley, PhD

Associate Professor of Neurology at University of Alabama at Birmingham

Location: Birmingham, AL United States

Laura Volpicelli-Daley earned her PhD in neuroscience from Emory University, where she studied receptor trafficking in Alzheimer’s and Parkinson’s diseases. During a short postdoctoral fellowship in the lab of Dr. Richard Kahn, she studied membrane trafficking. As a postdoctoral fellow in the lab of Dr. Pietro De Camilli at Yale University, she studied lipid metabolism in the brain. While her husband completed a fellowship in sleep disorders at UPenn, Dr. Volpicelli-Daley was a senior scientist in the lab of Dr. Virginia M.-Y. Lee and Dr. John Trojanowski. There, she discovered that fibrils of alpha-synuclein seed the growth of aggregates from endogenously produced alpha-synuclein in neurons. As associate professor at UAB, her lab focuses on the impact of pathologic alpha-synuclein on cognitive and motor symptoms in Parkinson’s disease. In addition, the lab studies how accumulation of glycosphingolipids in the brain causes synapse loss and cognitive decline.


Associated Grants

  • Understanding and Manipulating Cellular and Circuit-level Vulnerability to Neurodegeneration in Parkinson’s Disease

    2024


  • Further Validation of SIRT3 in a Parkinsonian Model

    2016


  • Defining Structural Forms of Alpha-synuclein Responsible for Key Features Associated with Parkinson's Disease

    2016


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