Nick Holford trained in internal medicine at the University of Manchester (United Kingdom) and subsequently in clinical pharmacology at the University of California, San Francisco. He continued in clinical practice in New Zealand (Auckland Hospital) for several years before devoting his attention to quantitative clinical pharmacology in drug development. 

Dr. Holford's research is focused on rational use of drugs through the application of quantitative principles. Specific topics include the changes in pharmacokinetics and dynamics associated with growth and aging (premature neonates to adults), improving clinical trial designs by computational simulation, evaluating the effect of drugs on disease progression (osteoporosis, depression, Alzheimer’s and Parkinson’s disease). Dr Holford was acclaimed as a Champion of PKPD at the 4th International Symposium on the Measurement and Kinetics of Drug Effect in the Netherland in 2006.