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Thomas M. Durcan, PhD

Associate Professor at Montreal Neurological Institute, McGill University

Location: Montreal Canada

Thomas Durcan is an associate professor at the Montreal Neurological Institute (The Neuro) and director of The Neuro’s Early Drug Discovery Unit. His research focuses on understanding the cell biology behind neurological disorders, including Parkinson’s disease (PD). His group at The Neuro uses the genome-editing tool CRISPR to develop imaging-based assays in brain cells derived from stem cells to advance our understanding of the causes of PD, amyotrophic lateral sclerosis (ALS) and neurodevelopmental disorders. His overall goal is to better understand why these diseases occur, while applying this insight towards the development of a translational program with industry partners to accelerate access to novel and next generation therapies for individuals living with neurodegenerative disorders. His research is supported by a range of funders, including Brain Canada, the Canadian Institutes of Health Research, CFREF/Healthy Brains for Healthy Lives, The Michael J. Fox foundation, Parkinson’s Canada and the U.S. Department of Defense.


Associated Grants

  • Tagging Genes Associated with Parkinson’s Disease Using the Gene-editing CRISPR Tool

    2021


  • Illuminating the Dark Genome of Parkinson’s Disease

    2021


  • Effects of LRRK2 Variants on GCase Activity in iPSC-derived Dopamine Neurons and Microglia

    2020


  • Small-Molecule Inhibitor of Alpha-Synuclein Propagation in the Treatment of Parkinson's Disease

    2017


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