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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • MJFF Research Grant, 2011
    LRRK2 GTPase Validation and Inhibitor Discovery

    Objective/Rationale: 
    Mutations have been found in two places in the LRRK2 protein in patients with familial Parkinson’s disease. These LRRK2 mutations cause increased LRRK2 protein activity, leading...

  • Target Validation, 2011
    Inhibition of LINGO-1 as a Novel Target for Regeneration in Pre-clinical PD Models

    Objective/Rationale: 
    LINGO-1 inhibits growth responses in the central nervous system and LINGO-1 expression is increased when nerve cells are exposed to injury. We have shown that LINGO-1 expression...

  • Target Validation, 2011
    Evaluation of ATP13A2 as a Molecular Target for Ameliorating Alpha-Synuclein-Induced Neurodegeneration in Pre-clinical Models of PD

    Objective/Rationale: 
    Mutations in the alpha-synuclein gene cause autosomal dominant Parkinson’s disease. While mutant forms of alpha-synuclein are toxic when introduced into neurons and pre-clinical...

  • MJFF Research Grant, 2011
    Generating Patient-Specific Induced Pluripotent Stem Cells to Study Parkinson's Disease

    Objective/Rationale:
    We have generated two lines of human dopamine neurons with parkin mutations and two lines from normal people using stem cells derived from their skin cells. Several interesting...

  • Antibody Comparison, 2011
    Analysis of LRRK2 Antibodies

    Objective/Rationale: 
    There is great hope that drugs targeting an enzyme termed LRRK2 may be useful in treating Parkinson’s disease (PD). There is therefore intense research taking place to better...

  • Antibody Comparison, 2011
    LRRK2 Immunocytochemistry in Cultured Neurons

    Objective/Rationale: 
    Several antibodies have been identified that recognize Leucine-Rich Repeat Kinase 2 (LRRK2), but uncertainty persists as to whether such antibodies are reliable in detecting ...

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