The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutics Development Initiative, 2010Metal Complexation with Levodopa to Improve Continuous Dopaminergic Stimulation
Objective/Rationale:
Our goal is to market a new levodopa/carbidopa orally-administered drug product with pharmacokinetics (PK) similar to that seen with direct infusion products. Currently, orally... -
Therapeutics Development Initiative, 2010Novel, Selective and Potent Brain-penetrant Small Molecule Inhibitors of Cytosolic Hsp90
Objective/Rationale:
Our objective is to develop novel drug candidates as therapeutics for Parkinson's disease by selectively targeting and inhibiting the heat shock protein-90 (Hsp90) in the brain... -
MJFF Research Grant, 2010Generation of Phosphospecific LRRK2 Antibodies
Objective/Rationale:
LRRK2 (Leucine-Rich Repeat Kinase 2) is a protein thought to be involved in regulating signaling pathways in cells. Mutations in the gene for LRRK2 are associated with some... -
MJFF Research Grant, 2010Generation of PINK1 Antibodies
Objective/Rationale:
PINK1 (PTEN-Induced Kinase 1) is a protein involved in regulating signaling pathways in the energy “powerhouse” of cells, known as mitochondria. Mutations in the gene for PINK1 are... -
Target Validation, 2010Gremlin-1, a Putative VTA-derived Neuroprotective Factor in Parkinson's Disease
Objective/Rationale:
We recently showed that certain brain neurons which are normally protected from Parkinson’s disease (PD) contain high levels of the developmental factor Gremlin-1. The goal of this... -
Target Validation, 2010Treating Early Cognitive Impairments and Associated Movement Control Deficits by Stimulating alpha4beta2* nAChRs
Objective/Rationale:
Cholinergic systems decline early in PD and are hypothesized to contribute to cognitive impairments as well as to impairments in performing complex movements and postural...
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Our funding programs support basic, translational and clinical research from academia and industry.