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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Biomarkers, 2011
    Salivary Biomarkers for Parkinson's Disease

    Objective/Rationale:
    Biomarkers are needed for assisting with the diagnosis of Parkinson’s disease (PD) and for monitoring its progression. To date, the most consistent observations pertain to...

  • MJFF Research Grant, 2011
    Analysis of the ENS Using Routine Colonic Biopsies as a Biomarker for PD: Optimizing Detection of Alpha-Synuclein Pathology and Assessment in LRRK2 Patients

    Promising Outcomes of Original Grant:
    In our original research funded by MJFF, we have shown that the enteric nervous system was readily analyzed using routine colonic biopsies obtained in the course...

  • LRRK2, 2011
    New Roles for the Parkinson's Disease Kinase LRRK2 in Cytoskeletal Dynamics

    Objective/Rationale:
    LRRK2, a key protein in Parkinson’s disease, may have a role in regulating the cytoskeleton. The cytoskeleton in nerve cells (neurons) is crucial for the growth of neuronal...

  • Therapeutics Development Initiative, 2011
    Xenon inhalation to reduce L-Dopa-induced dyskinesia

    Objective/Rationale:
    Levodopa is the most effective drug to treat symptoms of Parkinson’s disease, however long-term use leads to disabling levodopa-induced dyskinesia (LID) in the vast majority of...

  • Therapeutics Development Initiative, 2011
    Pharmacokinetics and Cognitive Side Effects of the Antidyskinetic Drug Fenobam in MPTP-treated Pre-clinical Models

    Promising Outcomes of Original Grant:
    The goal of our original project was to determine if a prodrug of acamprosate could inhibit levodopa-induced dyskinesias (LIDs) in a pre-clinical model. During...

  • LRRK2, 2011
    The Role of LRRK2 in Regulating a Calcium-Dependent Pathway Involving Lysosomal Stores and NAADP

    Objective/Rationale:
    Our preliminary evidence indicates that LRRK2 may regulate acidic calcium stores, with downstream effects on autophagy as well as a variety of other calcium dependent cellular...

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