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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Therapeutic Pipeline Program, 2014
    TDO Inhibitors: A New Treatment Option for Parkinson’s Disease

    Study Rationale:                   
    Tryptophan-2,3-dioxygenase (TDO) is a key enzyme in the tryptophan degradation pathway. In a Parkinson’s disease (PD) model, TDO was identified as a potential...

  • Research Grant, 2014
    PARK14-dependent SOCE and Sporadic Parkinson’s Disease

    Objective/Rationale:             
    Mutations in the PARK14 gene are associated with Parkinson’s disease (PD), but its role in idiopathic PD is presently unknown. Recently we identified a role of PARK14...

  • Target Validation, 2014
    Melanoma-related Gene as a Therapeutic Target for Parkinson's Disease

    Objective/Rationale:      
    Individuals with Parkinson’s disease (PD) are more likely to develop melanoma. Conversely, melanoma patients are at higher risk of developing PD. This bidirectional link...

  • Rapid Response Innovation Awards, 2014
    GSNOR Inhibition for Treatment of Parkinson’s Disease

    Study Rationale:                    
    Parkinson’s disease may be driven by inflammation and toxic, reactive products from oxygen metabolism. SAJE Pharma’s drugs target an enzyme called s...

  • Rapid Response Innovation Awards, 2014
    Drug Rescue of PINK1: New Therapeutic Modality for Treating Parkinson’s Disease

    Study Rationale:       
    Mitochondrial dysfunction has long been linked to Parkinson’s disease. We are investigating a class of drugs that increase the activity of an important mitochondrial quality...

  • Rapid Response Innovation Awards, 2014
    Functional Characterization of HIP1R in Parkinson’s Disease

    Study Rationale:                   
    Intracellular vesicle trafficking is an important mechanism for delivering proteins to their proper location where they can function within cells. Various genes...

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