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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • LRRK2 Role in Idiopathic Parkinson's Disease, 2014
    Non-dopaminergic Systems in the Evolution of LRRK2 Parkinsonism

    Objective/Rationale: 
    Researchers have previously demonstrated that the pattern and evolution of progressive changes in the dopamine system in Parkinson’s disease (PD) associated with LRRK2 mutations...

  • LRRK2 Role in Idiopathic Parkinson's Disease, 2014
    Activation of Microglial LRRK2 by Alpha-synuclein: LRRK2 Pathogenesis in Idiopathic PD

    Objective/Rationale:
    Alpha-synuclein is a protein that plays an important role in all forms of Parkinson’s disease (PD). Recent data demonstrate that brain cells can secrete alpha-synuclein and that...

  • LRRK2 Role in Idiopathic Parkinson's Disease, 2014
    Deciphering the Genetic Architecture of the LRRK2 Gene in the Indian Population

    Objective/Rationale:
    Genetic variability in the LRRK2 gene is recognized as one of the most common cause of Parkinson’s disease (PD) mainly in the Caucasian, African-Arab, Ashkenazi Jewish and East...

  • LRRK2 Role in Idiopathic Parkinson's Disease, 2014
    Assessing the Role of LRRK2 in Sporadic Parkinson’s Disease Using iPSC-derived Dopaminergic Neurons

    Objective/Rationale:
    Mutations in the LRRK2 gene are the greatest known contributors to genetic forms of Parkinson’s disease (PD). This project will investigate whether LRRK2 function also plays a role...

  • Research Grant, 2014
    LRRK2 Expression in Postmortem Brain

    Objective/Rationale:
    Mutations in LRRK2 are a major genetic cause of Parkinson’s disease. This study aims to determine what happens to the amount of LRRK2 protein in the brains of people with Parkinson...

  • Neurotrophic Factors Challenge, 2014
    Delivery of Cerebral Dopamine Neurotrophic Factor with Microbubbles and MRI-guided Focused Ultrasound

    Objective/Rationale:
    Neurotrophic drugs regenerate and protect brain cells damaged by Parkinson’s disease, but can’t penetrate the blood brain barrier (BBB). With direct needle or catheter drug...

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