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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023
    Discovering Ocular Biomarkers of Parkinson’s Disease

    Study Rationale: Early detection of Parksinson’s disease (PD) leads to improved care and better quality of life. However, the current methods for diagnosing PD, physical examination and brain imaging...

  • Lysosomal Biomarkers Program, 2023
    Development of Autophagy-lysosome Biomarkers for Parkinson’s Disease Using Stem Cell-derived Neurons and Biofluids

    Study Rationale: Genetic, molecular, and pathological studies have highlighted the role of dysfunctional mechanisms for clearing cellular debris — called autophagy-lysosome pathways — in the...

  • Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023
    Structure and Mechanism of PINK1-TOM Supercomplex Formation

    Study Rationale: Mitochondrial dysfunction plays an important role in the development and progression of Parkinson’s disease (PD). In healthy cells, when mitochondria become damaged, protein called...

  • Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023
    Evaluating the Impact of LRRK2 Mutation on Lysosomal Function in Macrophages

    Study Rationale: Mutations in LRRK2 are associated with inherited forms of Parkinson’s disease (PD). LRRK2 is a lysosomal protein that is produced in immune cells, such as macrophages. These cells are...

  • Lysosomal Biomarkers Program, 2023
    Investigating the Role of Lysosomal Biomarker ATP13A2 in the Pathogenesis of Parkinson’s Disease

    Study Rationale: Lysosomal impairment is strongly implicated in the pathology of Parkinson’s disease (PD). Loss-of-function mutations in ATP13A2, a gene that encodes a lysosomal protein, are causally...

  • Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023
    Analysis of the Lysosomal Lipid Metabolism Pathway and Other Pathways, Subgroups and Stages in Parkinson’s Disease

    Study Rationale: Lysosomes are cellular compartments involved in clearing molecular debris. Several genes that work in the lysosome, including GBA1, GALC, SMPD1 and others, are known to be involved in...

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