The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2021Preclinical Development of Immune-inhibiting Small Molecules as Therapeutics for Parkinson’s Disease
Study Rationale: Brain inflammation plays an important role in the pathology of Parkinson’s disease (PD). One of the key proteins involved in this inflammatory process is STING (stimulator of...
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Summer 2021 RFP: Expanding Biological Understanding of PD, 2021Assessment of LRRK2 Activity and Neurodegeneration Markers in Postmortem Brain Samples of Idiopathic and LRRK2-associated Parkinson’s Disease
Study Rationale: Genetic variance at the LRRK2 gene locus is associated with risk of Parkinson’s disease (PD). Most evidence suggests that this variation increases the activity of the encoded LRRK2...
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Outcome Measures, 2021Protective Effect of Immune Gene Subtype in Parkinson’s Disease
Study Rationale: Our genetic studies of Parkinson’s disease (PD) have found a protective effect of an immune gene called HLA-DR, specifically the presence of the HLA-DRB1*04 subtype. We found that HLA...
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Research Grant, 2021Changing Rhythms in Parkinson’s Disease: Development of Motor and Non-motor Markers of Progression Based on Continuous Daily Monitoring
Study Rationale: Although new treatments are being developed to slow the progression of Parkinson’s disease (PD), assessing their effectiveness remains a challenge. Standard evaluations, conducted in...
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Research Grant, 2021Gut Inflammation and Microbial Imbalance in Parkinson’s Disease
Study Rationale: Studies show that the intestinal environment can affect the activity of the nervous system, and inflammation in the gut could contribute to the brain changes associated with Parkinson...
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Therapeutic Pipeline Program, 2021Wireless “Nanoelectrodes” as a Minimally Invasive Alternative to Conventional Deep Brain Stimulation
Study Rationale: Deep Brain Stimulation (DBS) has been used to ease motor symptoms in people with Parkinson’s disease (PD). This approach requires a surgical procedure to implant electrodes into the...
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Our funding programs support basic, translational and clinical research from academia and industry.