Funded Studies

Study Rationale:

Nilotinib, a drug approved for chronic myelogenous leukemia, inhibits the protein c-Abl. Higher brain levels of c-Abl are associated with Parkinson's disease (PD), and laboratory...

Study Rationale:
Abelson tyrosine kinase (c-Abl) is believed to drive the deleterious events leading to loss of dopamine neurons in people with Parkinson's disease. This project will identify small...

Study Rationale:

To avoid accumulation of products that may cause toxicity, neurons rely on a series of highly efficient mechanisms of quality control. It has been proposed that, in those with...

Study Rationale:
Evidence suggests that alpha-synuclein can cause neuron death in Parkinson's disease (PD) by forming clusters (or aggregates) on the surface of small structures inside the cell called...

Study Rationale:
Mitochondria provide energy for neurons to function and survive. Evidence suggests that individuals with Parkinson's disease (PD) have poorly functioning mitochondria, such that the...

Study Rationale:
Although the precise mechanism(s) for neurodegeneration in Parkinson's disease (PD) is unknown, evidence suggests that neuroinflammation is an important contributor. In this study, we...