The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Target Advancement Program, 2022Alpha-synuclein Aggregation in the Brainstem: Developing a Model and Discovering a New Biomarker for Parkinson Disease
Study Rationale: Abnormal accumulation of alpha-synuclein (a neuronal protein) in distinct regions of the brain is a well known feature in Parkinson’s disease (PD). A sizeable number of people with PD...
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Target Advancement Program, 2022Development of an Antibody for Isolating Mitochondria from Preclinical Models and Individuals with Parkinson’s Disease
Study Rationale: Previous research has demonstrated that mitochondria — the energy-generating centers in the cell — are impaired in the brains of people with Parkinson’s disease (PD). However, the...
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Spring 2022 RFA: Target Advancement Program - Tool Generation, 2022Design and testing of a FRET sensor for Parkin activity
Study Rationale: Parkin is a protein that is encoded by a gene which is frequently mutated in Parkinson’s disease. It is known to be involved in getting rid of damaged mitochondria in cells and this...
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Proof-of-Concept Testing of PD Therapeutics, 2022Therapeutic Targeting of Mitochondrial Biogenesis to Address Parkinson’s Disease
Study Rationale: Parkinson’s disease (PD) is a complex disorder involving the degeneration of specific brain cells that lead to severe impairments in movement and cognition. Although the exact cause...
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Research Grant, 2022Shoring Up a Medical Chemistry Approach to Treating Parkinson’s Disease: The Bridge Initiative
Study Rationale: The proteins parkin and GCase show a strong genetic link to Parkinson’s disease (PD) and are key players of biological pathways often disrupted in the disorder. This connection makes...
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Parkinson’s Pathway Molecular Data Analysis Program, 2022Investigating the Role of Repeat Expansions and Mitochondrial Dysfunction in Parkinson’s Disease
Study Rationale: Both genetic mutations and exposure to environmental factors contribute to Parkinson’s disease (PD). Genetic risk for someone with PD could be due to multiple genes, different types...
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Our funding programs support basic, translational and clinical research from academia and industry.