The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Fall 2021 RFP: Outcome Measures, 2022Common Mitochondrial DNA Deletions as a Peripheral Marker of Parkinson’s Disease
Study Rationale: Mitochondria are small capsules inside cells that generate energy. There are lots of mitochondria in brain cells because the brain uses a lot of energy. Researchers have found that...
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Research Grant, 2022Expanding Genetic Analyses in Parkinson’s Disease
Study Rationale: There is a critical need for greater understanding of the genetic component of Parkinson’s disease, both to predict and diagnose disease, but also to inform drug development efforts...
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Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2022Using AZP2006 (Ezeprogind) to Stabilize Progranulin – A Novel Therapeutic Strategy for GBA1-linked Parkinson’s Disease
Study Rationale: Progranulin (PGRN) regulates cell growth, survival and changes. They are usually secreted or transported to the lysosome. Its deficiency and inflammation leads to a decline in the...
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Research Grant, 2022Development And Validation Of A Miro1 Biomarker Assay Using White Blood Cells
Study Rationale: The mitochondrial protein Miro1 fails to be degraded and this defect impairs mitophagy in more than 90% of all Parkinson’s disease (PD) patients of both genetic and sporadic forms...
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Research Grant, 2022RT-QuIC Testing of Misfolded α-Synuclein in Stage 4 Study; Submandibular Gland Biopsies and CSF Samples
Study Rationale: Normally folded a-synuclein protein is vital to normal brain function. However, misfolded a-synuclein can form the aggregated fibrils that contribute to Parkinson’s disease’s (PD)...
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Diversity, Equity and Inclusivity in Parkinson's research, 2022Parkinson’s Disease in Southern Africa
Study Rationale: Most studies on Parkinson’s disease (PD) are focused on patients in Europe and North America. It is crucial to investigate patterns and the causes PD in other parts of the world. It...
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Our funding programs support basic, translational and clinical research from academia and industry.