The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Target Advancement Program, 2017Farnesoid X Receptor to Reduce Neuroinflammation
Study Rationale:
Although the precise mechanism(s) for neurodegeneration in Parkinson's disease (PD) is unknown, evidence suggests that neuroinflammation is an important contributor. In this study, we... -
Therapeutic Pipeline Program, 2017Small-Molecule Inhibitor of Alpha-Synuclein Propagation in the Treatment of Parkinson's Disease
Study Rationale:
The notion of misfolded alpha-synuclein (alpha-syn) aggregates moving from neuron-to-neuron is a mechanism that is gaining widespread acceptance as a central mechanism in the... -
Therapeutic Pipeline Program, 2017Pre-clinical Development of LBT-3627, a Potential Neuroprotective and Anti-inflammatory Therapy for Parkinson's Disease
Study Rationale:
Adaptive and innate immune responses play important roles in neuroinflammation and can be harnessed to improve outcomes in Parkinson's disease (PD). Daily administration of LBT-3627... -
Research Grant, 2017Blood Proteins for the Treatment of Parkinson’s Disease
Study Rationale & Design:
Components of blood have been found to improve health and enhance multiple biological functions in pre-clinical studies of age-related decline. Blood plasma has been... -
Research Grant, 2017Using Deep Brain Stimulation to Understand and Treat Dystonia Associated with Parkinson’s Disease
Study Rationale:
Dystonia and Parkinson's disease (PD) are closely related movement disorders. Dystonia is characterized by painful, prolonged muscle contractions that cause involuntary, repetitive... -
LRRK2 Biology Consortium, 2017Investigating the Role of LRRK2 in Immunity and Susceptibility to Infection
Study Rationale:
One of the most common inherited causes of Parkinson's disease (PD) is defect in the LRRK2 protein caused by changes, or mutations, of the LRRK2 gene. Our previous studies have shown...
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Our funding programs support basic, translational and clinical research from academia and industry.