The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 Biology Consortium, 2017Describing the Structure and Function of LRRK2
Study Rationale:
Although leucine-rich repeat kinase 2 (LRRK2) is the greatest known genetic contributor to Parkinson's disease (PD), little is known about its structure and function. To better... -
Research Grant, 2017Using Neural Cells to Test New Drugs that Activate PINK1 and Parkin
Promising Outcomes of Original Grant:
Even though most people with Parkinson's disease (PD) do not have a genetic mutation -- a change in their DNA -- that causes the disease, genes can influence the... -
Research Grant, 2017Radioactive Molecules for Detection of Alpha-synuclein and Amyloid-beta in the Brain
Study Rationale:
We will develop radioactive alpha-synuclein and beta-amyloid tracers -- molecules that allow researchers and clinicians to detect these two proteins in the brain using imaging... -
Access to Data & Biospecimens, 2017Klotho and Parkinson’s disease
Study Rationale:
Genetic studies have identified a powerful “aging suppressor gene”, Klotho, that may play a role in delaying age-related declines in cellular and tissue functioning...
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Target Advancement Program, 2017Disruption of Pathological Protein-protein Interactions in Alpha-synuclein
Study Rationale:
The spread of alpha-synuclein (sticky protein that clumps in the brains of those with Parkinson's) occurs through a cell-to-cell prion-like (spreading) mechanism. Disrupting the... -
Therapeutic Pipeline Program, 2017Cell-Permeable Parkin Protein Suppresses Parkinson's Disease-associated Symptoms
Study Rationale:
The Parkin protein (encoded by the PARK2 gene that is linked to Parkinson's), has been shown to exert potent neuroprotective effects that could potentially be used to treat Parkinson's...
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Our funding programs support basic, translational and clinical research from academia and industry.