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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Access to Data and Biospecimens, 2014
    Metabolomic Analysis of Parkinsonian Disorders

    Study Rationale:
    This study is a search for biomarkers of Parkinson’s disease (PD) that would provide early diagnostic clues or a means to monitor disease progression (or both). The analysis involves...

  • Rapid Response Innovation Awards, 2014
    Directed Evolution of Bacteria for Recombinant Expression and Purification of LRRK2

    Study Rationale:                  
    Mutations in the gene that encodes the LRRK2 protein are frequent causes of Parkinson’s disease (PD). An obstacle to understanding how these mutations lead to PD is...

  • Rapid Response Innovation Awards, 2014
    Defining the Contribution of Neuroinflammation to Parkinson's Disease

    Study Rationale:                   
    Over-activation of brain immune cells, called microglia, is associated with the degeneration that occurs in Parkinson’s disease. This suggests that brain...

  • Therapeutic Pipeline Program, 2014
    Augmenting Treatment Effects of Voice Therapy in Parkinson’s Disease

    Study Rationale:                   
    Speech and voice disorders are common in people with Parkinson’s disease (PD) and adversely affect their communication and quality of life. Presently, Lee Silverman...

  • Improved Biomarkers and Clinical Outcome Measures, 2019
    Correlating MRI, Pathology and Cognitive Assessments toward Biomarkers of Cognitive Decline

    Study Rationale:
    Parkinson’s studies are working to identify magnetic resonance imaging (MRI) biomarkers for early diagnosis, disease severity and progression. However, attempts to explore how brain...

  • Improved Biomarkers and Clinical Outcome Measures, 2019
    International Validation of Two Non-motor Symptom Scales in Parkinson’s Disease

    Study Rationale:
    Non-motor Parkinson’s symptoms can fluctuate with dopaminergic medication effectiveness. Anxiety, sadness, lack of energy and fatigue are common symptoms during the off-medication...

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