The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Improved Biomarkers and Clinical Outcome Measures, 2018Developing a Test for Circular RNA, a Possible Biomarker of Parkinson's Disease
Study Rationale:
Circular RNA (circRNA) is a recently discovered type of RNA, a molecule that plays an important role in protein production. CircRNAs are abundant in the brain and builds up when... -
Target Advancement Program, 2018Evaluating the Role and Therapeutic Potential of Natural Killer Cells in Parkinson's Disease
Study Rationale:
Natural killer (NK) cells are immune cells that defend the body against external and internal threats. While the number of NK cells is increased in Parkinson's disease (PD), it... -
Therapeutic Pipeline Program, 2018Exosomal Delivery of shRNA Minicircles to Halt Neurodegeneration and Parkinson's
Study Rationale:
Gene therapy is one of the most promising tools for the treatment of Parkinson's disease (PD). We have developed a novel system to treat brain diseases using exosomes, which are small... -
Target Advancement Program, 2018Role of Neuromelanin in Parkinson's Disease and Brain Aging
Study Rationale:
In Parkinson's disease (PD), there is a selective degeneration of brain cells that contain the dark-brown pigment neuromelanin, especially dopamine-producing cells in part of the... -
Target Advancement Program, 2018Engineering Protective Immune Cells for the Treatment of Parkinson's Disease
Study Rationale:
Toxic proteins produced in the brains of people with Parkinson's disease (PD) are known to set off an immune response. In the course of this response, inflammatory lymphocytes --... -
Improved Biomarkers and Clinical Outcome Measures, 2018Searching for Signs of Parkinson's Disease in the Eye
Study Rationale:
Alpha-synuclein is a protein that clumps in the brains of people with Parkinson's disease (PD). These clumps have also been found in the brain and, recently, the retina -- the back of...
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Our funding programs support basic, translational and clinical research from academia and industry.