The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2011Structural, Post-translational Modification and Small Chemical Approaches to Understand LRRK2 Function in PD
Promising Outcomes of Original Grant:
Our original goal was to (1) establish electron microscopy (EM)-based dimeric structural assays for the LRRK2 protein and (2) develop high-throughput kinase assays... -
LRRK2, 2011Analytic Models in Biomarker Development
Objective/Rationale:
Non-invasive tests or biomarkers may aid clinical trials if they help to identify a subgroup of individuals at high risk of Parkinson's disease (PD), or if they are able to... -
Improving Levodopa Delivery, 2012Enhanced Dopamine Availability, Prolonged Activity and Improved Dyskinesia Profile After Administration of Selectively Deuterated Levodopa
Objective/Rationale:
To confirm the found beneficial effects of DP-102 (reduced dyskinetic effects at motoric equieffective doses in comparison to regular levodopa) in a pre-clinical model of Parkinson... -
LRRK2 Biology LEAPS, 2012Combining Mass Spectrometry with Genetic and Pharmacological Approaches to Discover and Validate LRRK2 Substrates
Objective/Rationale:
Much recent work has suggested that comprehending the biological properties of an enzyme termed LRRK2 that is mutated in about one percent of all Parkinson’s disease patients... -
Rapid Response Innovation Awards, 2012Development of Small Molecule Hepatocyte Growth Factor Mimetics for the Treatment of Parkinson’s Disease
Objective/Rationale:
The goal of this project is to determine the clinical potential of a novel, orally active hepatocyte growth factor mimetic for the prevention and/or treatment of Parkinson’s... -
MJFF Research Grant, 2012Development of Nurr1-RXR Heterodimer Selective Agonists for Parkinson's Disease
Promising Outcomes of Original Grant:
We hypothesized that Nurr1 could be targeted indirectly with small molecules through other nuclear hormone receptors, and that such compounds would have...
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Our funding programs support basic, translational and clinical research from academia and industry.