The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Freezing of Gait, 2024Adaptive Cortical Neuromodulation Using a Brain-machine Interface to Treat Freezing of Gait in Parkinson’s Disease
Study Rationale: Difficulties with walking can have significant impacts on the quality of life of people with Parkinson’s (PwP). One of the most serious is freezing of gait (FOG), which are brief but...
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Research Grant, 2024Validation of Functional Staging of Parkinson’s Disease Using the Critical Path for Parkinson’s (CPP) Integrated Parkinson’s Database
Study Rationale: Researchers recently proposed defining Parkinson’s disease (PD) based on a test for abnormal alpha-synuclein in spinal fluid and adopting a staging system based on measures (or scales...
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Parkinson’s Disease Therapeutics Pipeline Program, 2024A Novel Brain-penetrating Antibody for Treating Parkinson’s Disease
Study Rationale: Inflammation in the brain is an important trigger of Parkinson’s disease (PD). Our strategy is to block one of the key molecules mediating inflammation and degeneration in the brain...
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Parkinson’s Disease Therapeutics Pipeline Program, 2024Biomarker Development and IND-Enabling Toxicology Support for Novel, Small Molecules that Enhance Lysosomal Function for the Treatment of Parkinson’s Disease
Study Rationale: In people with Parkinson’s disease (PD), neurons exhibit decreased ability to remove cellular trash. This dysfunction is caused by a reduction in the number and effectiveness of the...
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Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2024Targeting Lipid Biology in Stem Cell-derived Neurons to Develop a New Therapeutic Drug for Parkinson’s Disease
Study Rationale: Neurons derived from the stem cells of people with Parkinson’s disease (PD) offer an excellent vehicle for identifying potentially disease-modifying therapeutic compounds. We...
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Parkinson’s Disease Therapeutics Pipeline Program, 2024Development of Brain-penetrant TrkB Agonist Antibody for Parkinson’s Disease
Study Rationale: Parkinson's disease (PD) is characterized by the death of dopamine neurons, which control movement. We have generated a novel therapeutic agent — an antibody that activates a receptor...
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Our funding programs support basic, translational and clinical research from academia and industry.