The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2013Validation of a Novel Pre-Clinical Model of Dyskinesia in PD
Promising Outcomes of Original Grant:
Our original target validation grant was aimed at deciphering the role of the protein beta-arrestin2 in the manifestation of beneficial versus dyskinetic side... -
Rapid Response Innovation Awards, 2013Topography of Vulnerability to Alpha-synuclein Fibrils in the Cerebral Cortex
Objective/Rationale:
In Parkinson’s disease, the neocortex (outer layer of the brain’s cerebral hemispheres, made of six layers) is less vulnerable than the allocortex (fewer than six... -
Rapid Response Innovation Awards, 2013Genetic Validation of a New Causative Gene for Familial and Sporadic Parkinson’s Disease
Objective/Rationale:
Genetic and environmental factors both have been linked to Parkinson’s disease (PD). Over the last 15 years, many PD susceptibility genes have been described. However... -
Target Validation, 2013The Role of the Protein FBXO7 in Parkinsonism
Objective/Rationale:
Increasing evidence points to an important role of genetics in Parkinson’s disease (PD). Causative mutations (alterations in the DNA sequence) have been found in many... -
Therapeutic Pipeline Program, 2013Study to Evaluate RM-131 Administered to Parkinson’s Patients with Chronic Constipation
Objective/Rationale:
The purpose of this study, called MOVE-PD, is to investigate how patients with Parkinson’s disease (PD) and chronic constipation respond to the drug RM-131. The study... -
LRRK2 Target Engagement Ligand, 2013LRRK2 Target Engagement Ligand (Supplement)
Promising Outcomes of Original Grant:
New compounds from several distinct series have been synthesized that have improved inhibition of the LRRK2 enzymatic kinase activity. We assessed their...
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Our funding programs support basic, translational and clinical research from academia and industry.