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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • MJFF Research Grant, 2010
    Generating and Characterizing LRRK2 Antibodies

    Objective/Rationale:
    LRRK2 is a gene implicated in the development of some familial Parkinson’s disease cases. Because of LRRK2’s significant potential as a drug target, MJFF is making considerable...

  • MJFF Research Grant, 2010
    Comparison and Actions of MANF and GDNF in Rodent Models of Parkinson's Disease

    Objective/Rationale
    Parkinson's disease (PD) is caused by the degeneration of certain dopaminergic neurons in the brain. Neurotrophic factors like GDNF protect dopaminergic neurons from degenerating...

  • MJFF Research Grant, 2010
    Viral Over-expression of Alpha Synuclein

    Promising Outcomes of Original Grant:
    In our previous grant, we attempted to create a bilateral model of PD using viral over expression of alpha-synuclein. The performance of the study was near...

  • MJFF Research Grant, 2010
    A Rodent Model of Pathological Gambling Associated with Medicated Parkinsonian Patients

    Promising Outcomes of Original Grant:
    In keeping with our original hypothesis, we determined the following:  1) Being in a parkinsonian state (i.e., following 6-OHDA-induced lesions) alters impulsivity...

  • Improving Delivery of Parkinson's Disease Therapeutics to th, 2010
    Novel Antibodies for the Delivery of Parkinson's Therapeutics

    Promising Outcomes of Original Grant:
    The initial granting period resulted in the successful identification of antibodies capable of targeting and internalizing into novel in vitro blood-brain barrier...

  • Target Validation, 2010
    Validation of VPS41, a Protein Involved in Lysosomal Trafficking, as a Target for Parkinson Disease Therapy

    Promising Outcomes of Original Grant:
    VPS41 was identified in a C. elegans system. In the original funded grant, we demonstrated that human VPS41 (hVPS41) was also protective in C. elegans, performed a...

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